iCARE articles
Blue rubber bleb nevus syndrome: A European multicenter cohort study.
Becq A, Bisdorff A, Riccioni ME, et al. Dig Liver Dis. 2025;57(2):603-608. doi:10.1016/j.dld.2024.10.001
Background and aim: Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare congenital vascular entity, mainly characterized by cutaneous and gastrointestinal venous malformations. BRBNS remains relatively unexplored and only limited descriptive data is available. The aim of this study was to evaluate the clinical features, diagnostic work-up and therapeutic management in current practice.
Evaluation of Colon Capsule Utilisation in Europe—CAPTURE EU Survey Findings.
Lei II, Robertson A, Koulaouzidis A, Arasaradnam R, et al. Journal of Clinical Medicine. 2025; 14(1):99.
Background/Objectives: Colon capsule endoscopy (CCE) is a non-invasive method for visualising the colon, but its clinical adoption has been slow. Although the COVID-19 pandemic reignited interest in CCE, its role in conventional gastrointestinal investigations remains unclear, leading to varied practices across Europe. This highlights the need for a comprehensive understanding of diverse approaches to CCE in clinical practice.
Endoscopic Gastrointestinal Placement of CapsuleEndoscopy to Investigate the Small Bowel: a Multicentric European RetrospectiveSeries of 630 Procedures in Adult Patients.
Ouazana S, Baltes P, Toth E, et al. Gastrointest Endosc. 2024;100(3):492–500.
Background and aims: Small bowel (SB) capsule endoscopy (CE) is a first line procedure for exploring the SB. Endoscopic GastroIntestinal PlacemenT (EGIPT) of SB CE is sometimes necessary. While the experience of EGIPT is large in pediatric populations, we aimed to describe the safety, efficacy and outcomes of EGIPT of SB CE in adult patients.
Where does capsule endoscopy fit in the diagnostic algorithm of small bowel intussusception?
Chetcuti Zammit S, Yadav A, McNamara D, et al. Dig Liver Dis. 2023;55(12):1719–1724.
Introduction: The investigation of small bowel (SB) intussusception is variable, reflecting the lack of existing standards. The aim of this study was to understand the role of small bowel capsule endoscopy (SBCE) to investigate this pathology.
Small-bowel capsule endoscopy in patients with Meckel’s diverticulum: clinical features, diagnostic workup, and findings. A European multicenter I-CARE study.
Baltes P, Dray X, Riccioni ME, et al. Gastrointest Endosc. 2023;97(5):917-926.e3.
Background and study aim: Meckel’s Diverticulum (MD) may remain silent or be associated with complications like gastrointestinal (GI) bleeding. The main aim of this study was to evaluate indicative small bowel capsule endoscopy (SBCE) findings and the secondary aim to describe clinical presentation in patients with MD.
Inter/Intra-Observer Agreement in Video-Capsule Endoscopy: Are We Getting It All Wrong? A Systematic Review and Meta-Analysis.
Cortegoso Valdivia P, Deding U, Bjørsum-Meyer T, et al. Diagnostics (Basel). 2022;12(10):2400. Published 2022 Oct 2.
Video-capsule endoscopy (VCE) reading is a time- and energy-consuming task. Agreement on findings between readers (either different or the same) is a crucial point for increasing performance and providing valid reports. The aim of this systematic review with meta-analysis is to provide an evaluation of inter/intra-observer agreement in VCE reading.
Score reproducibility and reliability in differentiating small bowel subepithelial masses from innocent bulges.
Sciberras M, Conti K, Elli L, et al. Dig Liver Dis. 2022;54(10):1403–1409.
Aims: The primary aim of this study was to assess the reliability, intra- and inter-observer variation of the SPICE, Mucosal protrusion angle (MPA) and SHYUNG scores in differentiating a subepithelial mass (SEM) from a bulge. Methods: This retrospective multicentre study analysed the 3 scores, radiological studies, enteroscopy and/or surgical findings.
Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy: A Delphi Consensus Statement of the International CApsule endoscopy REsearch (I-CARE) Group.
Elli L, Marinoni B, Sidhu R, et al. Diagnostics (Basel). 2022;12(7):1704. Published 2022 Jul 13.
Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized;
Small bowel capsule endoscopy in obscure gastrointestinal bleeding: A matched cohort comparison of patients with normal vs surgically altered gastric anatomy.
Dray X, Rahmi G, Riccioni ME, et al. Clin Res Hepatol Gastroenterol. 2022;46(7):101921.
Background: Little is known about small bowel capsule endoscopy (SBCE) outcomes in patients with surgically altered anatomy.
Aims: To assess the feasibility and diagnostic yield of orally ingested SBCE to investigate obscure gastrointestinal bleeding (OGIB) in patients with surgically altered gastric anatomy, compared to native gastric anatomy.
PEACE: Perception and Expectations toward Artificial Intelligence in Capsule Endoscopy.
Leenhardt R, Fernandez-Urien Sainz I, Rondonotti E, et al. J Clin Med. 2021;10(23):5708. Published 2021 Dec 6.
Artificial intelligence (AI) has shown promising results in digestive endoscopy, especially in capsule endoscopy (CE). However, some physicians still have some difficulties and fear the advent of this technology. We aimed to evaluate the perceptions and current sentiments toward the use of AI in CE.
Feasibility and diagnostic yield of small-bowel capsule endoscopy in patients with surgically altered gastric anatomy: the SAGA study.
Dray X, Riccioni ME, Wurm Johansson G, et al. Gastrointest Endosc. 2021;94(3):589–597.e1.
Background and aims: Little is known about small-bowel (SB) capsule endoscopy (CE) in patients with a history of gastric surgery. This study aims to evaluate the feasibility and diagnostic yield (DY) of orally ingested SB-CE in patients with surgically altered gastric anatomy.
A guide for assessing the clinical relevance of findings in small bowel capsule endoscopy: analysis of 8064 answers of international experts to an illustrated script questionnaire.
Leenhardt R, Koulaouzidis A, McNamara D, et al. Clin Res Hepatol Gastroenterol. 2021;45(6):101637.
Background and aim: Although recommended, the P-score used for assessing the pertinence / relevance of findings seen in small bowel (SB) capsule endoscopy (CE) is based on a low level of knowledge. The aim of this study was to evaluate the clinical relevance of the most frequent SBCE findings through an illustrated script questionnaire.
Nomenclature and semantic descriptions of ulcerative and inflammatory lesions seen in Crohn’s disease in small bowel capsule endoscopy: An international Delphi consensus statement.
Leenhardt R, Buisson A, Bourreille A, et al. United European Gastroenterol J. 2020;8(1):99–107.
Background: In the medical literature, the nomenclature and descriptions (ND) of small bowel (SB) ulcerative and inflammatory (U-I) lesions in capsule endoscopy (CE) are scarce and inconsistent. Inter-observer variability in interpreting these findings remains a major limitation in the assessment of the severity of mucosal lesions, which can impact negatively on clinical care, training and research on SB-CE.
Nomenclature and semantic description of vascular lesions in small bowel capsule endoscopy: an international Delphi consensus statement.
Leenhardt R, Li C, Koulaouzidis A, et al. Endosc Int Open. 2019;7(3):E372–E379.
Background and study aims: Nomenclature and descriptions of small bowel (SB) vascular lesions in capsule endoscopy (CE) are scarce in the medical literature. They are mostly based on the reader's opinion and thus differ between experts, with a potential negative impact on clinical care, teaching and research regarding SBCE. Our aim was to better define a nomenclature and to give a description of the most frequent vascular lesions in SBCE.
